Enhancing the Solubility and Dissolution Rate of Meclizine Hydrochloride by Inclusion Complex
Meclizine Hydrochloride is an Anti-Histamine drugs with very low bioavailability that can be improved by increasing its solubility and dissolution rate. The aim of this study is to enhance dissolution of Meclizine Hydrochloride as a model hydrophobic drug through application of inclusion complex technology. It was formulated as inclusion complex compact, and its dissolution property is evaluated and compared with marketed product of Meclizine Hcl tablet. The newly formulated drug and the interaction between excipients was examined by, Fourier-transform infrared spectroscopy, and differential scanning colorimetry, respectively. Both DSC and SEM results suggested loss of crystallinity of Meclizine Hydrochloride upon conversion into a inclusion complex formulation. The dissolution efficiency of Meclizine Hydrochloride at 45 min was increased from directly compressed tablet to 98.0% for marketed product to 97.2% at 45 minutes for the inclusion complex formulation. The increase in the dissolution rate was also found to be significant compared to the marketed product. The inclusion complex technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like Meclizine Hydrochloride.
Keywords: Meclizine Hydrochloride, inclusion complex, Avicel pH 102, Talc, Lactose, ethanol
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