Nanosponges: A Novel Trend for Targeted Drug Delivery
Effective targeted drug delivery system has been a dream for a long time, but it has been largely frustrated by the complex chemistry that is involved in the development of new systems. Topical drug delivery system has many problems like poor permeability, skin irritation, allergic reactions etc. major problems of newly developed chemical entities is their poor solubility in water and pharmacokinetic issues. These poorly-water soluble drugs show many problems in formulating them in conventional dosage forms and the critical problems associated is its very low bioavailability. The invention of Nanosponge has become a significant step towards overcoming these problems. Nanosponge is tiny sponges with a size about a virus (250nm-1um), which can be filled with a wide variety of drugs. Nanosponge play vital role in targeting drugs delivery in a controlled manner. This sponge can circulate around the body until interact with specific target site and stick on surface and releasing drug in controlled manner both lipophilic and hydrophilic drugs are incorporated in nanosponge . Important characteristics of these sponges are their solubility in aqueous from and suitable for the drugs with poor solubility. This review is focusing on the preparation method, applications of nanosponge, factor in the field of drug delivery.
Keywords: nanosponge, poor solubility, Biodegradable polymers, synthesis, preparation
2. K. Patel, and R. J. Oswald, Nanosponge And Micro Sponges: A Novel Drug Delivery System, International Journal Of Research In Pharmacy And Chemistry, IJRPC, 2012; 2(2): ISSN: 2231-2781, 237-244
3. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges. EP 1 786 841 B1; 2007
4. Trotta F, Tumiatti V, Cavalli R, Rogero C, Mognetti B, Berta G. Cyclodextrin-based nanosponges as a vehicle for Antitumoral drugs. WO 2009/003656 A1; 2009.
5. Liang L, De-Pei L, Chih-Chuan L, Optimizing the delivery systems of chimeric RNA DNA Oligonucleotides beyond general oligonucleotide transfer.Eur J Biochem.2002, 269, 5753–5758 7.
6. Aritomi H, Yamasaki Y, Yamada K, Honda, Khoshi M, Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. J Pharma Sci Tech.1996, 56(1), 49-568.
7. Yurtdas G, Demirel M, Genc L, Inclusion complexes of fluconazole with b-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation.J. Incl. Phenom. Macrocycl. Chem.2011, 70, 429–435;
8. Khalid A. Ansari, Pradeep R. Vavia, Francesco Trotta. Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterizations, Stability, Cytotoxicity and Permeation Study. AAPS Pharm Sci Tech, Vol. 12, 2011
9. 9.Zuruzi S, MacDonald NC, Moskovits M, Kolmakov A, Metal oxide nanosponges as chemical sensors: Highly sensitive detection of hydrogen using nanosponge titania; Angewandte Chem ie.2007, 46 (23): 4298-4301
10. Patil Bhagyashree and Dr. S. K. Mohite. Formulation Design & Development of Artesunate Nano sponge. Ejpmr, 2016, 3(5), 206-211. Amber V, Shailendra S, Swarnalatha S. Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem, 2008; 62:23-42.
11. Rajeswari C, Alka A, Javed A, Khar R K. Cyclodextrins in drug delivery: an update review. AAPS pharmSciTech, 2005; 6(2):E329-E357.
12. Renuka S, Roderick BW, Kamla P. Evaluation of the kinetics and mechanism of drug release from Econazole Nitrate nanosponge loaded carbapol hydrogel. Ind J Parm Edu Res, 2011; 45(1): 25-31. 8.
13. Renuka S, Kamla P. Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation Pharm Dev Technol. 2011;16(4):367-376.
14. Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm, 2010; 74: 193-201.
15. Wolfgang S (2007). Sample preparation in Light Scattering from Polymer Solutions and Nanoparticle Dispersions. Springer Berlin Heidelberg GmbH & Co. K. P43-4.
16. Renuka S and Kamla P (2011). Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topicalhydrogel formulation.Pharm DevTechnol: 367-376.
17. Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm. 2010, 74, 193201.
18. Jenny A, Merima P, Alberto F, Francesco T. Role of β- cyclodextrin nanosponges in polypropylene photooxidation, Carbohydrate Polymers. 2011, 86, 127– 135.
19. Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes – A Review. J Pharm Sci Tech. 2010, 2(3), 171-183
20. Amber V, Shailendra S, Swarnalatha S, Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem. 2008, 62, 23-42
21. Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes – A Review. J Pharm Sci Tech. 2010, 2(3), 171-183. 31. Amber V, Shailendra S, Swarnalatha S, Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem. 2008, 62, 23-42
22. Emanuele AD, Dinarvand R. Preparation, characterization and drug release from thermo responsive microspheres. Int J Pharm.1995, 237-242.
23. Martin A, Swarbrick J, Cammarrata A. In: Physical Pharmacy–Physical Chemical Principles in Pharmaceutical Sciences. 1991, 3, 527 33
24. Trotta F, Cavalli R, Vavia PR, Khalid A, J Incl Phenom Macrocycl Chem, 2011, Online first TM, DOI,10.1007/s10847-011-9926-5.
25. Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, Vavia PR, Int J Pharm, 2010, 402, 254-257.
26. Longo C, Gambara G, Espina V, Luchini A, Bishop B, Patanarut AS, Petricoin EF, Beretti F, Ferrari B, Garaci E, DePol A, Pellacani G, Liotta LA, Exp Dermatol, 2011, 20, 29-34.
27. Wong VN, Fernando G, Wagner AR, Zhang J, Kinsel GR, Zauscher S, Dyer DJ, Langmuir, 2009, 25, 1459-1465.
28. Schlichtenmayer M, Hirscher M, J Mater Chem, 2012, 22, 10134-10143.
29. Mamba BB, Krause RW, Malefetse TJ, Gericke G, Sithole SP, Water Institute of Southern Africa (WISA) Biennial Conference 2008, Sun City, South Africa, Special Edition, 2009, 35(2),
30. Lee CL, Huang YC, Kuo LC, Nanotech, 2006, 17, 2390-2395.
31. Bolmal UB, Manvi FV, Rajkumar K, Palla SS, Paladugu A, Reddy KR, Int J Pharm Sci Tech, 2013, 6(1), 19341944.
32. Trotta F, Cavalli R, Vavia PR, Khalid A, J Incl Phenom Macrocycl Chem, 2011, Online first TM, DOI,10.1007/s10847-011-9926-5.
33. Yadav G, Panchory H, J Drug Del Therap, 2013, 3(4), 151-155
34. Mamba BB, Krause RW, Malefetse TJ, Gericke G, Sithole SP, Water Institute of Southern Africa (WISA) Biennial Conference 2008, Sun City, South Africa, Special Edition, 2009, 35(2), 56.
35. Adebajo MO, Frost RL, Kloprogge JT, Carmody O, Kokot S, J Porous Materials, 2003, 10, 159-170.
36. Che-Ming J, Ronnie HF, Jonathan C, Brian TL, Liangfang Z, Nature Nanotech Letters, 2013, 54, 1-5.
37. Yang CY, Liao TC, Shuai HH, Shen TL, Yeh JA, Cheng CM, Biomaterials, 2012, 33(20), 4988-4997
38. Jenny A, Merima P, Visakh PM, Alberto F, Giulio M, Carbohydrate Polymers, 2012, 88, 1387-1394.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).