Preparation and Characterization of Nanomicelle for Ocular delivery of fluoroquinolone derivative
Abstract
Pluronic nanomicelles were prepared for Ocular delivery by incorporation of methyl alcohol as a dispersing agent and the surface was modifying by chitosan to improve the bioavailability. Nanomicelle dispersed well in solution and having a core shell-like structure with particle range from 100-350 nm and zeta potential between 5.45mV -18.98mV indicating very suitable use as an ophthalmic carrier. The turbidity test reveals that the prepared nanomicelle were very stable under simulated tear fluid environment and simulated tear fluid, which prevent the blurred vision. The drug entrapment of ciprofloxacin hydrochloride in nanomicelle was too much high 98.07±6.8040. Finally, the drug release indicates the Pluronic nanomicelle modify by chitosan have sustained release behavior. As a result of Pluronic-Chitosan nanomicelle system provide a potential opportunity in decreasing dosing frequency of administration and improving patient compliance for ocular drug delivery.
Keywords: Chitosan, Nanomicelle, Ocular delivery system, Poloxamer 407.
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References
1. Vaishya RD, Khurana V, Patel S, Mitra AK. Controlled ocular drug delivery with nanomicelles, Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2014; 6(5):422-37.
2. Weng YH, Ma XW, Che J, Li C, Liu J, Chen SZ, Nanomicelle-Assisted Targeted Ocular Delivery with Enhanced Antiinflammatory Efficacy In Vivo. Advanced science. 2018; 5(1):1700455.
3. Li M, Xin M, Song K, Sun F, Hou Y, Li J, Evaluation of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer nanomicelle for trigeminal ganglion neurons delivering with intranasal administration. Current eye research. 2018; 43(3):406-14.
4. Guo C, Li M, Qi X, Lin G, Cui F, Li F, Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Scientific reports. 2016; 6:29753.
5. Kahraman E, Nesetoglu N, Gungor S, Unal DS, Ozsoy Y, The combination of nanomicelles with terpenes for enhancement of skin drug delivery, International journal of pharmaceutics. 2018; 551(1-2):133-40.
6. Wu X, Ge W, Shao T, Wu W, Hou J, Cui L, Enhancing the oral bioavailability of biochanin A by encapsulation in mixed micelles containing Pluronic F127 and Plasdone S630. International journal of nanomedicine. 2017; 12:1475-83.
7. Xin J, Wang S, Wang B, Wang J, Wang J, Zhang L, AlPcS4-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic((R)) F127 nanomicellar drug carriers. International journal of nanomedicine. 2018; 13:2017-36.
8. Mahmoodzadeh F, Jannat B, Ghorbani M. Chitosan-based nanomicelle as a novel platform for targeted delivery of methotrexate. International journal of biological macromolecules. 2019; 126:517-24.
9. Farhangi M, Kobarfard F, Mahboubi A, Vatanara A, Mortazavi SA. Preparation of an optimized ciprofloxacin-loaded chitosan nanomicelle with enhanced antibacterial activity. Drug development and industrial pharmacy. 2018; 44(8):1273-84.
10. Soliman GM, Attia MA, Mohamed RA. Poly(ethylene glycol)-block-poly(epsilon-caprolactone) nanomicelles for the solubilization and enhancement of antifungal activity of sertaconazole. Current drug delivery. 2014; 11(6):753-62.
11. Ashjari M, Khoee S, Mahdavian AR, Rahmatolahzadeh R. Self-assembled nanomicelles using PLGA-PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values. Journal of materials science Materials in medicine. 2012; 23(4):943-53.
12. Hekmat A, Attar H, Seyf Kordi AA, Iman M, Jaafari MR , New Oral Formulation and in Vitro Evaluation of Docetaxel-Loaded Nanomicelles. Molecules. 2016; 21(9).
13. Bao L, Bian L, Zhao M, Lei J, Wang J. Synthesis and self-assembly behavior of a biodegradable and sustainable soybean oil-based copolymer nanomicelle. Nanoscale research letters. 2014; 9(1):391.
14. Zhang L, Ren D, Zhou J, Peng G, Shu G, Yuan Z, Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study. Colloids and surfaces B, Biointerfaces. 2018; 163:125-32.
15. Ding S, Liu N, Li X, Peng L, Guo X, Ding W. Silica nanotubes and their assembly assisted by boric acid to hierachical mesostructures. Langmuir : the ACS journal of surfaces and colloids. 2010; 26(7):4572-5.
16. Ladmiral V, Semsarilar M, Canton I, Armes SP. Polymerization-induced self-assembly of galactose-functionalized biocompatible diblock copolymers for intracellular delivery. Journal of the American Chemical Society. 2013; 135(36):13574-81.
17. Xu Y, Lu Y, Wang L, Lu W, Huang J, Muir B, Nanomicelles based on a boronate ester-linked diblock copolymer as the carrier of doxorubicin with enhanced cellular uptake. Colloids and surfaces B, Biointerfaces. 2016; 141:318-26.
2. Weng YH, Ma XW, Che J, Li C, Liu J, Chen SZ, Nanomicelle-Assisted Targeted Ocular Delivery with Enhanced Antiinflammatory Efficacy In Vivo. Advanced science. 2018; 5(1):1700455.
3. Li M, Xin M, Song K, Sun F, Hou Y, Li J, Evaluation of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer nanomicelle for trigeminal ganglion neurons delivering with intranasal administration. Current eye research. 2018; 43(3):406-14.
4. Guo C, Li M, Qi X, Lin G, Cui F, Li F, Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Scientific reports. 2016; 6:29753.
5. Kahraman E, Nesetoglu N, Gungor S, Unal DS, Ozsoy Y, The combination of nanomicelles with terpenes for enhancement of skin drug delivery, International journal of pharmaceutics. 2018; 551(1-2):133-40.
6. Wu X, Ge W, Shao T, Wu W, Hou J, Cui L, Enhancing the oral bioavailability of biochanin A by encapsulation in mixed micelles containing Pluronic F127 and Plasdone S630. International journal of nanomedicine. 2017; 12:1475-83.
7. Xin J, Wang S, Wang B, Wang J, Wang J, Zhang L, AlPcS4-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic((R)) F127 nanomicellar drug carriers. International journal of nanomedicine. 2018; 13:2017-36.
8. Mahmoodzadeh F, Jannat B, Ghorbani M. Chitosan-based nanomicelle as a novel platform for targeted delivery of methotrexate. International journal of biological macromolecules. 2019; 126:517-24.
9. Farhangi M, Kobarfard F, Mahboubi A, Vatanara A, Mortazavi SA. Preparation of an optimized ciprofloxacin-loaded chitosan nanomicelle with enhanced antibacterial activity. Drug development and industrial pharmacy. 2018; 44(8):1273-84.
10. Soliman GM, Attia MA, Mohamed RA. Poly(ethylene glycol)-block-poly(epsilon-caprolactone) nanomicelles for the solubilization and enhancement of antifungal activity of sertaconazole. Current drug delivery. 2014; 11(6):753-62.
11. Ashjari M, Khoee S, Mahdavian AR, Rahmatolahzadeh R. Self-assembled nanomicelles using PLGA-PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values. Journal of materials science Materials in medicine. 2012; 23(4):943-53.
12. Hekmat A, Attar H, Seyf Kordi AA, Iman M, Jaafari MR , New Oral Formulation and in Vitro Evaluation of Docetaxel-Loaded Nanomicelles. Molecules. 2016; 21(9).
13. Bao L, Bian L, Zhao M, Lei J, Wang J. Synthesis and self-assembly behavior of a biodegradable and sustainable soybean oil-based copolymer nanomicelle. Nanoscale research letters. 2014; 9(1):391.
14. Zhang L, Ren D, Zhou J, Peng G, Shu G, Yuan Z, Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study. Colloids and surfaces B, Biointerfaces. 2018; 163:125-32.
15. Ding S, Liu N, Li X, Peng L, Guo X, Ding W. Silica nanotubes and their assembly assisted by boric acid to hierachical mesostructures. Langmuir : the ACS journal of surfaces and colloids. 2010; 26(7):4572-5.
16. Ladmiral V, Semsarilar M, Canton I, Armes SP. Polymerization-induced self-assembly of galactose-functionalized biocompatible diblock copolymers for intracellular delivery. Journal of the American Chemical Society. 2013; 135(36):13574-81.
17. Xu Y, Lu Y, Wang L, Lu W, Huang J, Muir B, Nanomicelles based on a boronate ester-linked diblock copolymer as the carrier of doxorubicin with enhanced cellular uptake. Colloids and surfaces B, Biointerfaces. 2016; 141:318-26.
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Singh P, Verma N. Preparation and Characterization of Nanomicelle for Ocular delivery of fluoroquinolone derivative. JDDT [Internet]. 15Apr.2019 [cited 17Apr.2024];9(2-s):355-6. Available from: https://www.jddtonline.info/index.php/jddt/article/view/2529
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