Indian Medicinal Plants with Antidiabetic Potential
Abstract
Medicinal plants should be evaluated extensively to determine the active principles present in them that are responsible for the hypoglycemic activity of these plants. Herbal drugs have gained popularity among the general population due to their ability to treat ailments with minimum side effects. The multi-target approaches of medicinal plants make them least susceptible to failure during the treatment therapy. Medicinal plants showing prominent anti-diabetic activity during the initial studies should be further explored to identify the active principles present in them that can become the promising drug candidates for the disease treatment in the coming future.
Keywords: Anti-diabetic, Diabetes Mellitus, Insulin, hypoglycemic, anti-hyperglycemic, anti-hyperlipidemic
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References
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[12] Selvan VT, Manikandan L, Kumar GPS, Suresh R, Kakoti BB, Gomathi P et al. “Antidiabetic and antioxidant effect of methanol extract of Artanemasesamoides in Streptozotocin-induced Diabetic rats”. International Journal of Applied Research in Natural Products, 2008; 1(1):25-33.
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[14] Pari L, Satheesh MA. “Antidiabetic activity of Boerhaavia diffusa L. effect on hepatic key enzymes in experimental diabetes”. Journal of Ethnopharmacology, 2004; 91(1):109-113.
[15] Deore SL, Khadabadi SS, Daulatkar VD, Deokate UA, Farooqui IU. “Evaluation of hypoglycemic and antidiabetic activity of bark of Butea monosperma”. Pharmacognosy Magazine; 2008 4(13):134-138.
[16] Parameshwar S, Srinivasan KK, Rao CM. “Oral Antidiabetic Activities of Different Extracts of Caesalpinia bonducella Seed Kernels”. Pharmaceutical Biology,2002; 40(8):590-595.
[17] Hakki;m FL, Girija S, Kumar RS, Jalaludeen MD. “Effect of aqueous and ethanol extracts of Cassia auriculata L. flowers on diabetes using alloxan induced diabetic rats”. International Journal of Diabetes & Metabolism, 2007; 15:100-106.
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[20] Sharma S, Chaturvedi M, Edwin E, Shukla S, Sagrawat H. “Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis”. International Journal of Diabetes, 2007; 27(2):56-59.
[21] Rao RB, Murugesan T, Sinha S, Saha BP, Pal M, Mandal SC. “Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats”. Phytotherapy Research, 2002; 16(6), 590-592.
[22] Mahalingam G, Krishnan K. “Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats”. International Journal of Diabetes, 2008; 28(1): 6-10.
[23] Venkatesh S, Thilagavathi J, ShyamSundar D. “Anti-diabetic activity of flowers of Hibiscus rosasinensis”, Fitoterapia, 2008; 79(2):79-81.
[24] Pankaj NK, Alam M, Roy BK, “Antidiabetic activity of seed powder of Holarrhena antidysenterica in rabbits”. Journal of Research, Birsa Agricultural University, 2006.
[25] Syamsudin, Inawati, Winarno H. “The effect of inai (Lawsonia inermis) leaves extract on blood glucose level: an experimental study”. Research Journal of Pharmacology, 2008; 2(2):20-23
[26] Eddouks M, Maghrani M, Zeggwagh NA, Michel JB. “Study of the hypoglycaemic activity of Lepidium sativum L. aqueous extract in normal and diabetic rats”. Journal of Ethnopharmacology, 2008; 97:391-395.
[27] Cakici I, Hurmoglu C, Tunctan AB, Kanzik NI, Sener B. “Hypoglycemic effects of Momordica charantia extract in normoglycaemic or cyproheptadin induced hyperglycaemic mice”. Journal of Ethnopharmacology, 1994; 44(2):117-122.
[28] Somani RS, Singhai AK. “Hypoglycaemic and antidiabetic activities of seeds of Myristica fragrans in normoglycaemic and alloxan-induced diabetic rats”. Asian journal of experimental sciences, 2008; 22(1):95-102.
[29] Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Wahab YHA. “Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic ß-cells”. Journal of Endocrinology, 2006; 189:127-136.
[30] Augusti KT. “Studies on the effects of a hypoglycaemic principle from Allium cepa”. Indian Journal of medicinal research, 1973; 6(7):1066-1071.
[31] Jasmin HB, Narasimhacharya AVRL. “Comparative antidiabetic, hypolipidemic, and antioxidant properties of Phyllanthus niruri in normal and diabetic rats”. Pharmaceutical Biology 2007; 45(7):569-574.
[32] Indian Council of Medical Research (I.C.M.R), Collaborating Centres. Flexible dose open trial of Vijayasar in cases of newly diagnosed non-insulin dependent diabetes mellitus, New Delhi. Indian Journal of Medical Research, 1998; 108:24-29.
[33] Nilambari D, Shrikant T, Vipinchandra PA. “Comprehensive Review of Rubia cordifolia Linn.” Pharmacognosy Reviews, 1998 2(3):124-134.
[34] Kumar GPS, Arunselvan P, Kumar DS, Subramanian SP. “Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin-induced diabetic rats”. Journal of Health Science, 2006; 52(3):283-291.
[35] Stanely P, Prince M, Menon VP. “Hypoglycemic and other related action of Tinospora cordifolia roots in alloxan induced diabetic rats”. Journal of Ethnopharmacology, 2000; 70(1):9-15.
[36] Zia T, Hasan SN, Hasan SK. “Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice”. Journal of Ethnopharmacology, 2001; 75(2-3):191-195.
[37] Kumar RU, Kasturirenghan S, Mariashibu TS, Manoharan R, Vasudevan RA, Sei CK et al. “Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on Alloxan-induced diabetic rats”. Int. J. Mol. Sci, 2009; 10:2367-2382
[2] Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33 Suppl 1(Suppl 1):S62-9
[3] A. Ramchandran, Know the signs and symptoms of diabetes. Indian J Med Res. 2014; 140(5):579-81
[4] Shiao-Wei Shen, Rubin Bressle,Oral hypoglycemic agents,Disease-a-Month.1976; 22(5):2-35
[5] Wadood A, Wadood N, Shah SA. “Effects of Acacia arabica and Carallumedulis on blood sugar levels of normal and alloxan diabetic rabbits”. Journal of Pakistan Medical Association, 1989; 39(8):208-212
[6] Tanko Y, Yerima M, Mahdi MA, Yaro AH, Musa KY, Mohammed A. “Hypoglycemic Activity of Methanolic Stem Bark of Adansonniadigitata Extract on Blood Glucose Levels of Streptozocin-Induced Diabetic Wistar Rats”. International Journal of Applied Research in Natural Products, 2008; 1(2):32-36
[7] Hong Gao, Yi-Na Huang, Bo Gao, Peng Li, Chika Inagaki and Jun Kawabata. “Inhibitory effect on α-glucosidase by Adhatoda vasica Nees.” Food Chemistry; 2000; 108(3): 965-972.
[8] Sabu MC, Ramadasan K. “Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties”. Indian Journal of Physiology and Pharmacology,2001; 48(1):81-88.
[9] Ajabnoor MA. “Effect of aloes on blood glucose level in normal and alloxan diabetic mice”. Journal of Ethnopharmacology, 1990; 8:215-220.
[10] Nalamolu Koteswara Rao. “Anti-Hyperglycemic and renal protective activities of Andrographis paniculata roots chloroform Extract”. Iranian Journal of Pharmacology & Therapeutics, 2006; 5:47-50.
[11] Kumar V, Khanna AK, Khan MM, Singh R, Singh S, Chander R et al. “Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats”. Indian Journal of Clinical Biochemistry, 2009; 24(1):65-69.
[12] Selvan VT, Manikandan L, Kumar GPS, Suresh R, Kakoti BB, Gomathi P et al. “Antidiabetic and antioxidant effect of methanol extract of Artanemasesamoides in Streptozotocin-induced Diabetic rats”. International Journal of Applied Research in Natural Products, 2008; 1(1):25-33.
[13] Chattopadhyay RR, Chattopadhyay RN, Nandy AK, Poddar G, Maitra SK. “The effect of fresh leaves of Azadirachta indica on glucose uptake and glycogen content in the isolated rat hemi diaphragm”. Bulletin of the Calcutta School of Tropical Medicine, 1987; 35:8-12,.
[14] Pari L, Satheesh MA. “Antidiabetic activity of Boerhaavia diffusa L. effect on hepatic key enzymes in experimental diabetes”. Journal of Ethnopharmacology, 2004; 91(1):109-113.
[15] Deore SL, Khadabadi SS, Daulatkar VD, Deokate UA, Farooqui IU. “Evaluation of hypoglycemic and antidiabetic activity of bark of Butea monosperma”. Pharmacognosy Magazine; 2008 4(13):134-138.
[16] Parameshwar S, Srinivasan KK, Rao CM. “Oral Antidiabetic Activities of Different Extracts of Caesalpinia bonducella Seed Kernels”. Pharmaceutical Biology,2002; 40(8):590-595.
[17] Hakki;m FL, Girija S, Kumar RS, Jalaludeen MD. “Effect of aqueous and ethanol extracts of Cassia auriculata L. flowers on diabetes using alloxan induced diabetic rats”. International Journal of Diabetes & Metabolism, 2007; 15:100-106.
[18] Kamble SM, Kamlakar PL, Vaidya S, Bambole VD. “Influence of Coccinia indica on certain enzymes in glycolytic and lipolytic pathway in human.” Indian Journal of Medical Science, 1998; 52(4):143-146.
[19] Ravi K, Sivagnanam K, Subramanian S. “Antihyperlipidemic effect of Eugenia jambolana seeds kernels on streptozotocin induced diabetes in rats”. Journal of Medicinal Food, 2004; 72(2):187-191.
[20] Sharma S, Chaturvedi M, Edwin E, Shukla S, Sagrawat H. “Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis”. International Journal of Diabetes, 2007; 27(2):56-59.
[21] Rao RB, Murugesan T, Sinha S, Saha BP, Pal M, Mandal SC. “Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats”. Phytotherapy Research, 2002; 16(6), 590-592.
[22] Mahalingam G, Krishnan K. “Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats”. International Journal of Diabetes, 2008; 28(1): 6-10.
[23] Venkatesh S, Thilagavathi J, ShyamSundar D. “Anti-diabetic activity of flowers of Hibiscus rosasinensis”, Fitoterapia, 2008; 79(2):79-81.
[24] Pankaj NK, Alam M, Roy BK, “Antidiabetic activity of seed powder of Holarrhena antidysenterica in rabbits”. Journal of Research, Birsa Agricultural University, 2006.
[25] Syamsudin, Inawati, Winarno H. “The effect of inai (Lawsonia inermis) leaves extract on blood glucose level: an experimental study”. Research Journal of Pharmacology, 2008; 2(2):20-23
[26] Eddouks M, Maghrani M, Zeggwagh NA, Michel JB. “Study of the hypoglycaemic activity of Lepidium sativum L. aqueous extract in normal and diabetic rats”. Journal of Ethnopharmacology, 2008; 97:391-395.
[27] Cakici I, Hurmoglu C, Tunctan AB, Kanzik NI, Sener B. “Hypoglycemic effects of Momordica charantia extract in normoglycaemic or cyproheptadin induced hyperglycaemic mice”. Journal of Ethnopharmacology, 1994; 44(2):117-122.
[28] Somani RS, Singhai AK. “Hypoglycaemic and antidiabetic activities of seeds of Myristica fragrans in normoglycaemic and alloxan-induced diabetic rats”. Asian journal of experimental sciences, 2008; 22(1):95-102.
[29] Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Wahab YHA. “Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic ß-cells”. Journal of Endocrinology, 2006; 189:127-136.
[30] Augusti KT. “Studies on the effects of a hypoglycaemic principle from Allium cepa”. Indian Journal of medicinal research, 1973; 6(7):1066-1071.
[31] Jasmin HB, Narasimhacharya AVRL. “Comparative antidiabetic, hypolipidemic, and antioxidant properties of Phyllanthus niruri in normal and diabetic rats”. Pharmaceutical Biology 2007; 45(7):569-574.
[32] Indian Council of Medical Research (I.C.M.R), Collaborating Centres. Flexible dose open trial of Vijayasar in cases of newly diagnosed non-insulin dependent diabetes mellitus, New Delhi. Indian Journal of Medical Research, 1998; 108:24-29.
[33] Nilambari D, Shrikant T, Vipinchandra PA. “Comprehensive Review of Rubia cordifolia Linn.” Pharmacognosy Reviews, 1998 2(3):124-134.
[34] Kumar GPS, Arunselvan P, Kumar DS, Subramanian SP. “Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin-induced diabetic rats”. Journal of Health Science, 2006; 52(3):283-291.
[35] Stanely P, Prince M, Menon VP. “Hypoglycemic and other related action of Tinospora cordifolia roots in alloxan induced diabetic rats”. Journal of Ethnopharmacology, 2000; 70(1):9-15.
[36] Zia T, Hasan SN, Hasan SK. “Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice”. Journal of Ethnopharmacology, 2001; 75(2-3):191-195.
[37] Kumar RU, Kasturirenghan S, Mariashibu TS, Manoharan R, Vasudevan RA, Sei CK et al. “Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on Alloxan-induced diabetic rats”. Int. J. Mol. Sci, 2009; 10:2367-2382
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Chhipa A, Sisodia S. Indian Medicinal Plants with Antidiabetic Potential. JDDT [Internet]. 15Jan.2019 [cited 18Apr.2024];9(1):257-65. Available from: https://www.jddtonline.info/index.php/jddt/article/view/2282
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