PREPARATION, CHARACTERIZATION AND EVALUATION OF NEBIVOLOL LOADED CHITOSAN NANOPARTICLES

  • Mayank Sharma School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore-452001, India
  • Rajesh Sharma School of Pharmacy Devi Ahilya Vishwavidyalaya Takshashila Campus, Khandwa Road (Ring Road) Indore-452001, India
  • Dinesh Kumar Jain College of Pharmacy, IPS Academy Knowledge Village, Rajendra Nagar A.B. Road, Indore-452012

Abstract

Nebivolol (NEB) is an antihypertensive drug with poor oral bioavailability (12%) in humans due to extensive first pass hepatic metabolism. Present work is an attempt to improve oral bioavailability of nebivolol by incorporating it with biodegradable polymer chitosan and preparing its nanoparticles. The results indicated stable nanoperticles with the value of ZP to be +36.4 mV ± 2 mV, the small particle size of 79.23 ± 45 nm and high entrapment efficiency of 72.56%. The in vitro release study revealed sustained release of drug for 72 h with 71.24% cumulative drug release. The promising results from the study revealed the applicability of chitosan in the formulation of NEB loaded CNPs.

Keywords: Nebivolol, chitosan, ionic gelation technique, nanoparticles, oral bioavailability, poor water solubility

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Author Biographies

Mayank Sharma, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore-452001, India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore-452001, India

Rajesh Sharma, School of Pharmacy Devi Ahilya Vishwavidyalaya Takshashila Campus, Khandwa Road (Ring Road) Indore-452001, India
Professor and Head, School of Pharmacy Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road (Ring Road) Indore-452001, India
Dinesh Kumar Jain, College of Pharmacy, IPS Academy Knowledge Village, Rajendra Nagar A.B. Road, Indore-452012
Professor and Principal, College of Pharmacy, IPS Academy Knowledge Village, Rajendra Nagar A.B. Road, Indore-452012

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Sharma M, Sharma R, Jain D. PREPARATION, CHARACTERIZATION AND EVALUATION OF NEBIVOLOL LOADED CHITOSAN NANOPARTICLES. JDDT [Internet]. 14Mar.2018 [cited 31Oct.2020];8(2):118-22. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1730