Synthesis and antihyperlipidemic activity of Dibenz[c,e]azepine-5,7-dione derivatives in Triton WR-1339-induced hyperlipidemic rats

  • Minakshi Verma Assistant Professor, Department of Pharmacy, G.S.V.M. Medical College Kanpur U.P., India
  • Ashish Kumar Gupta Assistant Professor, Department of Pharmacy, V.B.S.Purvanchal University Jaunpur U.P., India
  • Ravindra Nath Thakur Professor, Department of Pharmacy, G.S.V.M. Medical College Kanpur U.P., India

Abstract

The structural requirements for decreasing cholesterol and triglyceride levels remain largely uninvestigated. Thus a systematic investigation of certain N-substituted dibenz[c,e]azepines is necessary. Nine compounds of N-substituted derivatives of Dibenz[c,e]azepine-5,7-Dione were synthesized and they were tested for antihyperlipidemic activity. Compounds synthesized (C-1, C-3, C-4 and C-5) significantly lowered the serum total cholesterol, triglyceride and LDL (low density lipoprotein) levels and also improved the HDL (high density lipoprotein) level in Triton-WR 1339 induced hyperlipidemic rats.

Keywords: antihyperlipidemic activity, lipids in plasma, high density lipoprotein

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Author Biographies

Minakshi Verma, Assistant Professor, Department of Pharmacy, G.S.V.M. Medical College Kanpur U.P., India
Assistant Professor, Department of Pharmacy, G.S.V.M. Medical College Kanpur U.P., India
Ashish Kumar Gupta, Assistant Professor, Department of Pharmacy, V.B.S.Purvanchal University Jaunpur U.P., India

Assistant Professor, Department of Pharmacy, V.B.S.Purvanchal University Jaunpur U.P., India

Ravindra Nath Thakur, Professor, Department of Pharmacy, G.S.V.M. Medical College Kanpur U.P., India
Professor, Department of Pharmacy, G.S.V.M. Medical College Kanpur U.P., India

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Verma M, Gupta A, Thakur R. Synthesis and antihyperlipidemic activity of Dibenz[c,e]azepine-5,7-dione derivatives in Triton WR-1339-induced hyperlipidemic rats. JDDT [Internet]. 14Mar.2018 [cited 30Oct.2020];8(2):129-35. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1684