FORMULATION AND EVALUATION OF SUBLINGUAL TABLET CONTAINING ANTIEMETIC DRUG

  • Sheetal Sem Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India
  • Avinash Sharma Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India
  • Ashish Gupta Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India
  • G N Darwhekar Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Abstract

The aim of the present research is to formulate a sublingual tablet of antiemetic drug. Doxylamine succinate is an antihistaminic commonly used for the prevention and treatment of nausea and vomiting. Oral bioavailability of doxylamine succinate is low and shows extensive hepatic metabolism. The Objective of the present research is to formulate doxylamine succinate sublingual tablet to avoid hepatic first-pass metabolism and to improve its bioavailability. Sublingual route not only overcome the problem of dysphagia but also giving the rapid onset of action by enhancing permeability through site of administration

Keywords: Sublingual tablet, Doxylamine succinate, Antiemetic, Dysphagia, Bioavailability

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Author Biographies

Sheetal Sem, Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Avinash Sharma, Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Ashish Gupta, Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

G N Darwhekar, Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

Acropolis Institute of Pharmaceutical Education and Research, Indore, Bypass Road Manglia Square, Indore (M.P.) 453771, India

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Sem S, Sharma A, Gupta A, Darwhekar G. FORMULATION AND EVALUATION OF SUBLINGUAL TABLET CONTAINING ANTIEMETIC DRUG. JDDT [Internet]. 14Mar.2018 [cited 30Oct.2020];8(2):107-11. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1680