DEVELOPMENT AND IN VITRO EVALUATION OF AN ORAL FLOATING TABLET OF METRONIDAZOLE

  • Harshal Soni GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.
  • Chetan Ghulaxe GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.
  • Surbhi Upadhyay GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.
  • Sujit Pillai GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

Abstract

The present study was undertaken with an aim to develop and evaluate gastroretentive floating tablets of Metronidazole  that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. The floating tablets of Metronidazole were made by direct compression method using polymer Carbopol 934 and sodium bicarbonate and citric acid as gas generating agent. The tablets were evaluated by pre and post compression parameters such as weight variation, thickness, friability, hardness, drug content, in- vitro buoyancy studies and in-vitro dissolution studies and results were within the limits. Hardness was found to be in the range of 7.6 ± 0.27 kg/ cm² to 7.9 ± 0.35 kg/cm², the percent friability was in the range of 0.48% to 0.52% w/w and the tablets showed 94%  to 97% uniformity in drug content. The in-vitro dissolution studies were carried out in a USP type- II apparatus in 0.1N HCl. The formulations were able to within 2-7 minutes and showed buoyancy >12 hrs. The drug-polymer ratio, viscosity grades of Carbopol 934 and gas generating agents were found to influence the release of drug and floating characteristics from the prepared floating drug delivery system of Metronidazole. Kinetically, among the 4 assessed models the release pattern of Metronidazole from the tablets fitted best to Higuchi’s and zero order indicated that diffusion is the predominant mechanism controlling the drug release.

Keywords: Metronidazole, Floating tablets, Carbopol 934, Gastroretentive, Dissolution

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Author Biographies

Harshal Soni, GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

Chetan Ghulaxe, GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

Surbhi Upadhyay, GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

Sujit Pillai, GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

GRY Institute of Pharmacy, Vidhya Vihar, Borawan (Khargone) - 451228, M.P., India.

References

1. Vyas S.P., Khar RK, “Textbook of Controlled drug delivery, concepts and advances” ,Vallabh Prakashan , New Delhi, first edition, 2002, P.P. 196-217.
2. Chein YW. Novel Drug Delivery Systems ed by Chein YW, Marcel Dekker, Inc., New York, USA 1992; 139-196.
3. Gurjar G., Bhowmick M., Rathi V., Rathi J. Design and evaluation of extended release cefuroxime axetil floating tablets with improved GI absorption. Journal of Drug Delivery and Therapeutics, 2017; 7(1):49-59. doi:10.22270/jddt.v7i1.1352
4. Keshari A., Tripathi D., Srivastava, A. Vishwas R. Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics, 2015; 5(6):43-55. doi:10.22270/jddt.v5i6.1176
5. Sahoo C., Rao S., Sudhakar M. Formulation and evaluation of controlled porosity osmotic pump tablets for zidovudine and lamivudine combination using fructose as osmogen. Journal of Drug Delivery and Therapeutics, 2017; 7(4):41-50. doi:10.22270/jddt.v7i4.1465
6. Momin S., Khan S., Ghadage D., Yadav A., Wagh A. Formulation and evaluation of bilayer tablets of propranolol hydrochloride. Journal of Drug Delivery and Therapeutics, 2017; 7(2):50-57. doi:10.22270/jddt.v7i2.1399
7. Amritha V., Kaur S , Pandey K, formulation and in vitro evaluation of floating tablets of hydroxypropylmethylcellulose K4M and carbopol using Metronidazole as model drug, International Journal of Pharmaceutical Science and Research, 2014; 2244-2249
8. Pant S, Badola A, Kothiyal P, A review on gastroretentive drug delivery system, Indian Journal of Pharmaceutical Science and Research. 2016; 4(2) :1-10
9. Dubey J, Verma N, Floating drug delivery system: A review, Indian Journal of Pharmaceutical Science and Research, 2013; 2893-2899
10. Yerikala R., Pudi V., Saravanakumar K., Vadhireddy S. Formulation and evaluation of floating drug delivery of cefotaxime using raft forming approach. Journal of Drug Delivery and Therapeutics, 2017; 7(4):110-119. doi:10.22270/jddt.v7i4.1473
11. Sharma A., Sharma P., Darwhekar G. Formulation and evaluation of bilayer tablet of metronidazole and dicyclomine hydrochloride for treatment of irritable bowel disease. Journal of Drug Delivery and Therapeutics, 2017; 7(7):56-58. doi:10.22270/jddt.v7i7.1586
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1.
Soni H, Ghulaxe C, Upadhyay S, Pillai S. DEVELOPMENT AND IN VITRO EVALUATION OF AN ORAL FLOATING TABLET OF METRONIDAZOLE. JDDT [Internet]. 14Mar.2018 [cited 30Oct.2020];8(2):83-6. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1673