ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF SIMVASTATIN BY USING SOLID DISPERSION TECHNIQUE ALONG WITH DIFFERENT COMBINATION OF POLYMERS

  • Komal Komal Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India
  • Taranjit Kaur Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India
  • Ajeet Pal Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India
  • Amar Pal Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India
  • Prachi Sharma Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Abstract

The solubility and dissolution rate of simvastatin, a drug used for the treatment of hyperlipidaemia. Simvastatin is a selective competitive inhibitor of HMG Co A reductase. However its absolute bioavailability is 5%. To increase the solubility of drug solid dispersion was prepared. Solid dispersion preliminary solubility analysis was carried out for the selection of the carrier and solid dispersion was prepared with Hydroxy Propyl Methyl Cellulose (HPMC) and Methyl Cellulose (MC). These solid dispersions were analyzed for the solubility and in-vitro dissolution profile solid dispersion of drug with polymer has shown enhanced solubility with improved dissolution rate. Further FTIR, X-Ray studies were carried out. Solid dispersion prepared with polymer in 1:5 ratios shows the presence of amorphous form confirmed by the characterization study. The study also shows that dissolution rate of simvastatin can be enhanced to considerable extent by solid dispersion technique with Polymer.

Keywords: Solubility enhancement, Solid dispersion, Low aqueous solubility

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Author Biographies

Komal Komal, Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Taranjit Kaur, Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Ajeet Pal Singh, Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Amar Pal Singh, Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Prachi Sharma, Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Jalandhar, Punjab, India

References

1. Bhirud Y, Phalak H, Advances in solid dispersion technology and its applications in the development of solid dosage forms. Journal of Drug Delivery and Therapeutics, 2016; 6(6):40-47. doi:10.22270/jddt.v6i6.1316
2. Dwivedi C, Sahu R, Tiwari S, Satapathy T, Roy A, Role of liposome in novel drug delivery system. Journal of Drug Delivery and Therapeutics, 2014; 4(2):116-129. doi:10.22270/jddt.v4i2.768
3. Asadujjaman M, Mishuk A, Novel approaches in lipid based drug delivery systems. Journal of Drug Delivery and Therapeutics, 2013; 3(4):124-130. doi:10.22270/jddt.v3i4.578
4. Loftsson T, Hreinsdóttir D, Másson M, Evaluation of cyclodextrin solubilization of drugs, International journal of pharmaceutics, 2005, 302(1), 18-28.
5. Singh J, Walia M, Harikumar S, Solubility enhancement by solid dispersion method: a review, Journal of Drug Delivery and Therapeutics, 2013; 3(5):148-55.
6. Bikiaris D, Papageorgiou GZ, Stergiou A, et al., Physicochemical studies on solid dispersions of poorly water-soluble drugs: evaluation of capabilities and limitations of thermal analysis techniques, Thermochimica acta, 2005, 439(1), 58-67.
7. Khan A, Singh L, Various techniques of bioavailability enhancement: a review. Journal of Drug Delivery and Therapeutics, 2016; 6(3):34-41. doi:10.22270/jddt.v6i3.1228
8. Mehta S, Joseph NM, Feleke F, Palani S, Improving solubility of BCS class II drugs using solid dispersion: a review, Journal of Drug Delivery and Therapeutics, 2014, 4(3), 7-13.
9. Shende M, Fiske P, Fabrication and optimization of novel glipizide sustained release matrices for solubility and dissolution enhancement by solid dispersion through hydrophillic carriers. Journal of Drug Delivery and Therapeutics, 2017; 7(6):38-48. doi:10.22270/jddt.v7i6.1538
10. Armstrong NA. Pharmaceutical Experimental Design and Interpretation, 2n ed., Taylor & Francis Group; 2006.
11. Ambike Anshuman .A, Mahadik .R.k., Paradkar 2005 Spray- Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg In Vitro and invivo Evaluations Pharmaceutical Research P No.990-998.
12. Seoung Wook Jun , Min-Soo Kim , Jeong-Soo Kim , Hee Jun Park , Sibeum Lee, Jong Soo Woo Sung-Joo Hwang Preparation and characterization simvastatin/hydroxypropyl-b-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process European Journal of Pharmaceutics and Biopharmaceutics, 66 (2007) 413–421.
13. Verma S, Patel U, Patel R, Formulation and evaluation of ivermectin solid dispersion. Journal of Drug Delivery and Therapeutics, 2017; 7(7):15-17.
14. Nagasamy VD, Arun R, Saraswathi S, Padma Priya MS, Khan NI, Kathirulla N, Sruthi S, Dissolution enhancement of diacerein using water soluble carrier by solid dispersion technology, Journal of Drug Delivery and Therapeutics. 2017; 7(5):33-41 DOI: http://dx.doi.org/10.22270/jddt.v7i5.1503
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1.
Komal K, Kaur T, Singh A, Singh A, Sharma P. ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF SIMVASTATIN BY USING SOLID DISPERSION TECHNIQUE ALONG WITH DIFFERENT COMBINATION OF POLYMERS. JDDT [Internet]. 14Mar.2018 [cited 31Oct.2020];8(2):32-0. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1668