STUDIES ON MICROCRYSTALLINE CELLULOSE OBTAINED FROM SACCHARUM OFFICINARUM 2: FLOW AND COMPACTION PROPERTIES
Microcrystalline cellulose (MCC) derived from Saccharum officinarum stem was evaluated for its powder flow and compaction properties in order to assess its suitability as a potential direct compression excipient in tablet formulations. Â Alpha (Î±) cellulose obtained from different sodium hydroxide and bleaching treatments of dried shred S. officinarum stem pulp were hydrolyzed with 2.5 N Hydrochloric acid (2.5 N HCl) to obtain MCC which was coded MCC-Sacc. This was compared with a commercial brand, Avicel PH 102. Results of some powder flow parameters were: Bulk and tapped density (0.41 Â± 0.01 and 0.54 Â± 0.01 g/mL) respectively, particle density (1.82Â Â± 0.10), porosity (81.69 Â± 0.20), Carrâ€™s index (31.47 Â± 0.75 %), Hausnerâ€™s quotient (1.47), angle of repose (31.00 Â± 1.00 Â°) and these indices indicate poor flowability. Kawakita model assessment of powder showed good densification and cohesiveness. Compacts of MCC-Sacc showed good uniformity of weight, friability, disintegration and mechanical strength. The Heckel model showed good plasticity and slippage of the material. Values obtained were comparable to Avicel PH 102 in terms of compressibility and mechanical strength, hence MCC-Sacc has a good potential for use as a pharmaceutical excipient in direct compression formulation procedure.
Keywords: Microcrystalline cellulose, Saccharum officinarum, Avicel PH 102, powder, compaction.
2. Battista OA, Microcrystalline cellulose. In Bilkales NM, Segal L. (eds), Cellulose and Cellulose Derivatives. John Wiley and Sons, New York, USA, 1971, pp. 1265-1276.
3. Umeh ONC, Nworah AC, Ofoefule SI, Physicochemical properties of Microcrystalline cellulose derived from Indian bamboo (Bambusa vulgaris), Int. J. Pharm. Sci. Rev. Res., 2014; 29 (2):5-9.
4. Ohwoavworhua FO, Adekunle TA, Okahmafe OA, Processing pharmaceutical grade microcrystalline cellulose from groundnut husk: Extraction methods and characterization, Int. J.Green Pharm.,2009; 3(2):97-104.
5. Elâ€“Sakhawy M, Hassan ML, Physical and Mechanical Properties of Microcrystalline cellulose from agricultural residues, Carbohydrate Polymers, 2005; 67:1-10.
6. Anand SM, Chawla JS, (1981), Microcrystalline cellulose from hosiery waste, Research and Industry, 1981; 26:227-235.
7. Azubuike CP, Esiaba J, Investigation into some Physicoâ€“Technical and Tabletting Properties of low crystallinity powdered cellulose prepared from corn residues, Journal of Pharmaceutical Research and Opinion, 2012; 2(8):94-98.
8. Ohwoavworhua FO, Adelakun TA, A nonwood fiber production of microcrystalline cellulose from Sorghum caudatum: characterization and tableting properties, Indian J. Pharm. Sci. 2010; 72(3):295-301.
9. Suryadi H, Sutriyo, Sari HR, Rosikhoh D, Preparation of Microcrystalline cellulose from water hyacinth powder by enzymatic hydrolysis using cellulose of local isolate, J. Young Pharm., 2017, 9(1): 19-23.
10. Nwachukwu N and Ugoeze KC. Studies on Microcrystalline cellulose obtained from Saccharum officinarum 1: Processing and Physicochemical Properties, European Journal of Biomedical and Pharmaceutical Sciences, 2018; 5(2):42-48.
11. Hai HD, Saccharum officinarum, downloaded on 15/2/2018 @ world wide vegetables.ebly.com
12. Ohwoavworhua FO, Ogah E., Kunle OO, Preliminary investigation of physicochemical and functional properties of alpha cellulose obtained from waste paper: A potential pharmaceutical excipient, Journal of Raw Material Research, 2005; 2:84-93.
13. Adedokun MO, Nkori RE, Preliminary investigation of Mechanical Properties of Paracetamol Tablets Formulated With Microcrystalline Cellulose Binder Derived From Saccharum officinarum, L. Asian Journal of Biomedical and Pharmaceutical Sciences, 2014; 4(38):17-22.
14. Onyishi IV, Chime SA, Okoroji CA, Physicochemical Properties of Microcrystalline Cellulose from Saccharum officinarum: Comparative Evaluation with Avicel PH 101, American Journal of Pharm. Tech. Research, 2013; 3(5):414-426.
15. Ohwoavworhua FO, Adelakun TA, Some Physical Characteristics of microcrystalline cellulose obtained from raw cotton of Cochlospermum planchonii, Trop. J. Pharm. Res. 2005: 4(2):501-507.
16. Ugoeze KC, Nwachukwu N, Nwodo CC, Excipient Functionality of a Novel Hydrophilic Biopolymer derived from Ipomoea batatas Tubers. Indo American Journal of Pharmaceutical Research, 2017; 7(7):360-368
17. Sihtola H, Kyrkxund B, Laamansn L, Palbmius I, Comparison and conversion of viscosity and DP values determined by different methods. Pan. Puu. 1963; 45:225-232.
18. Neuman BS, The Flow Properties of Powders, Advances in Pharmaceutical Sciences, Academic Press, London, 1967, pp. 181-188.
19. Kawakita K, Ludde KH, Some considerations on powder compression equations, Powder Technol., 1970/1971; 4:61.
20. British Pharmacopoeia. Vol.II, Her Majesty Stationary Office, University Press, Cambridge, 2012; A326:327.
21. Ofoefule SI, Textbook of Pharmaceutical Technology and Industrial Pharmacy, Samakin Nig. Enterprises, Lagos, 2006, pp.24 â€“ 68.
22. United States Pharmacopoeia, USP 32, Vol. 2, The United States Pharmacopoeial Convention, Rockville M.D., 2009, pp.2113-2116, 3017.
23. Duberg M, Nystrom C, Studies on direct compression of tablets VI. Evaluation of methods for the estimation of particle fragmentation during compaction. Acta Pharm. Suec., 1982; 19:421-436.
24. Humbert-Droz P, Gurney R, Mordier D, Doelker E, Densification behavior of drugs presenting availability problems, Int. J. Pharm. Tech, Prod. Mfr, 1983; 4:29-35.
25. Odeku OA, Itiola OA, Compaction Properties of Three Types of Starch, Iranian Journal of Pharmaceutical Research, 2007; 6(1):17-23
26. Fox CD, Richman MD, Reier GE, Shangraw RF, Drug Cosm. Ind., 1963, 92:161
27. Huttenrauch R, Shangraw RF, J. Pharm. Sci., 1966; 55:510
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