DEVELOPMENT OF CLARITHROMYCIN GASTRORETENTIVE MICROSPHERES

  • Priya Jain IPS Academy College of Pharmacy, Indore (M.P.) 452012, India
  • Dinesh Kumar Jain IPS Academy College of Pharmacy, Indore (M.P.) 452012, India
DOI https://doi.org/10.22270/jddt.v7i7.1594

Abstract

Gastroretentive microspheres of clarithromycin were prepared on the principle of cation induced gelification using sodium alginate and pectin. These microspheres were investigated for micromeritic properties, drug entrapment, mucoadhesion and drug release properties. Microspheres were found to be discrete, spherical and free flowing. Microspheres were found to adhere to gastric mucosa with high affinity and showed controlled drug release.

Downloads

Download data is not yet available.

Author Biographies

Priya Jain, IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

Dinesh Kumar Jain, IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

References

1. Rajaonarivony M, Vauthier C, Couarraze G, Development of a new drug carrier made from sodium alginate, JPS, 1993, 82, 912–917.
2. Tripathi GK, Formulation and evaluation pH stimuli sensitive multiparticulate delivery system of Clarithromycin for the treatment Of Helicobacter pylori, IJPTR, 2013, 5, 7-16.
3. Lehr CM, Bouwstra JA, Schacht EH, Junginger HE, In vitro evaluation of mucoadhesive properties of chitosan and some other polymers, IJP, 1992, 78, 43-48.
Crossmark
Statistics
149 Views | 197 Downloads
How to Cite
1.
Jain P, Jain D. DEVELOPMENT OF CLARITHROMYCIN GASTRORETENTIVE MICROSPHERES. JDDT [Internet]. 21Dec.2017 [cited 18Apr.2024];7(7):81-3. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1594
Issue
Vol 7 No 7 (2017): VOLUME 7, ISSUE 7, 2017 (Special Issue: IPSAPHARM)
Section
Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).