FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE USING 32 FACTORIAL DESIGN
Abstract
The fast dissolving tablets of Promethazine Theoclate were prepared by sublimation technique, using 32 full factorial design. This research work aimed to study and to develop a unique drug delivery system for immediate release of drugs which can dissolve readily when placed in the oral cavity. The different subliming agents (Camphor, Urea and Menthol) in varying concentration (5-15% w/w) were used to develop the tablets. Total 12 formulations were prepared and evaluated for pre-compression and post compression characteristics. The optimization of the batches was carried out using 32 full factorial design and results of polynomial equation were analyzed using ANOVA and regression analysis. By the use of desirability approach final optimized formulation was prepared.
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References
2. Garg A, Gupta M, Taste masking and formulation development & evaluation of mouth dissolving tablets of levocetrizine dihydrochloride. Journal of Drug Delivery and Therapeutics, 2013; 3(3):123-130. doi:10.22270/jddt.v3i3.514
3. Mishra DN, Vijaya KSG, Rapidly disintegrating oral tablets of meloxicam, Indian Drugs, 2006, 43, 117-121.
4. Zhao N, Augsburger LL, Functionally compression of 3 classes of superdisintegrants in promoting aspirin tablet disintegration and dissolution, AAPS PharmSciTech, 2005, 6, 634-640.
5. Khan S, Kataria P, Nakhat P, Yeole P, Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets, AAPS PharmSciTech, 2007,8, E1-E7.
6. Sreenivas SA, Gadad AP, Dandagi PM, Mastiholimath VS, Patil MB, Formulation and evaluation of ondansetron hydrochloride directly compressed mouth disintegrating tablets, Indian Drugs, 2006, 43, 35-38.
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