NOVEL MULTIPARTICULATE DRUG DELIVERY SYSTEM OF CARVEDILOL AS ANTIHYPERTENSIVE DRUG
The main objectives of present work was to design and evaluate pellets of Carvedilol in order to increase patient compliance and therapeutically benefits. The pellets were made by the sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in stomach for long time. Hence sodium bicarbonate and hydroxyl propyl methyl cellulose are the key ingredients of this dissertation work. In vitro release trials were evaluated in response to check release of drug from the drug coated spheres. The release pattern of batches T1 to T6 was observed to vary due to variation in the concentration of HPMC 5cps, low substituted HPC and PVP K30. The trials T1-T3 showed the slow drug release due to combination of PVP K30 with low substituted HPC and HPMC 5cps; while the formulation T4-T6 showed the good release behavior as compare to T1-T3.
Keywords: Carvedilol, Multiparculate, Pellets, TLC, HPLC.
2. Kappor D, Patel M, Vyas R, Lad C, & Tyagi B. A review on microsponge drug delivery system. Journal of Drug Delivery and Therapeutics, 2014; 4(5):29-35. doi:10.22270/jddt.v4i5.978
3. Kapoor, D. Fabrication and characterization of non steroidal anti-inflammatory alginate beads for sustained release using natural polymer. Journal of Drug Delivery and Therapeutics, 2017; 7(2):77-80. doi:10.22270/jddt.v7i2.1401
4. Thakkar H, Patel N, Amodwala S. Formulation development of controlled release mucoadhesive beads of capecitabine. Journal of Drug Delivery and Therapeutics, 2016; 6(3):42-50. doi:10.22270/jddt.v6i3.1252
5. Kajale A, Chandewar A. Formulation and evaluation of oral floating beads of tramodol hydrochloride. Journal of Drug Delivery and Therapeutics, 2016; 6(4):7-16. doi:10.22270/jddt.v6i4.1270
6. Shaji J, Chadawar V, Talwalkar P. Multiparticulate Drug transport system. The Indian Pharmacist. 2007; 6(60):21-28.
7. Zhang Z. Multi-Component Drug Delivery of Paclitaxel. Journal of Drug Delivery and Therapeutics, 2017; 7(3):80-83. doi:10.22270/jddt.v7i3.1451.
8. Laila F, Chandran S. Multiparticulate formulation method to colon specific drug delivery cutting-edge perspectives. J. Pharm Pharm Sci. 2006; 9(3):327-338.
9. Shah D, Patel B, Shah C. Nanosuspension technology: a innovative slant for drug delivery system and permeability enhancer for poorly water soluble drugs. Journal of Drug Delivery and Therapeutics, 2015; 5(1):10-23. doi:10.22270/jddt.v5i1.995.
10. Schmidt C, Bodmeier R. A multiparticulate drug-transport system based totally on pellets included into congealable polyethylene glycol carrier substances. Int. J. Pharm. 2001; 216: 9-16.
11. 8,,Schmidt C., Kleinebudde P. have an impact on of the granulation step on pellets prepared via extrusion/ Spheronization. Chem. Pharm Bull. 1999; 45 (3): 405-412.
12. Agarwal D, Ranawat M, Chauhan C, Kamble R. Formulation and charecterisation of colon targeted pH dependent microspheres of capecitabine for colorectal cancer. Journal of Drug Delivery and Therapeutics, 2014; 3(6):215-222. doi:10.22270/jddt.v3i6.747
13. Mehta AM, Valazza MJ, Abele SE. evaluation of fluidized-mattress methods for enteric coating systems. Pharm. Technology. 1986; 46- 48.
14. Patil S, Gupta V. Design and in vitro evaluation of multiparticulate system for the chronomodulated delivery of lornoxicam. Journal of Drug Delivery and Therapeutics, 2015; 5(3):62-71. doi:10.22270/jddt.v5i3.1148
15. Thoma okay, Ziegler I. The pH independent release of fenoldopam from pellets with insoluble film coats. Eur J Pharm and Biopharm. 1998; 47(1):105-113.
16. Umprayn OK, Chitropas P, Amarekajorn S. development of terbutaline sulphate sustained release lined pellets. Drug Dev. Ind. Pharm. 1999; 25(4):477-491.
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