SYNTHESIS OF ZnO NANOGEL FOR THE TREATMENT OF SUPERFICIAL SKIN MICROBIAL INFECTIONS
Abstract
Zinc oxide (ZnO) nanogel is an antimicrobial gel comprising of ZnO nanoparticles. Since, in nanoparticles, the surface to volume ratio is very large, therefore, ZnO nanogel is more effective for the treatment of superficial skin microbial infections as compared to other gels comprising ZnO and that has processed through traditional methods. Generally, infected skins are affected by bacterial strains which are attached to the surface of the skin by forming biofilms. The cause of attachment of these biofilms with the skin may be due to the electrostatic, van der walls, dipole-dipole and H-bonding hydrophobic types of interactions. ZnO nanogel when applied to the microbial infected skin reduces the microbial adhesion and biofilm formation. This screening characteristic of gel is due to the presence of ZnO nanoparticles of pore diameter 12.4 nm in the gel.  The nanoparticles of ZnO is synthesized using sol-gel method and characterized by  X - ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS) and high resolution transmission scanning electron microscopy (HRTEM). The minimum inhibitory concentration (MIC) data tells that ZnO nanoparticles of such a small pore diameter inhibit the growth of microbes present on the skin surface.
Keywords: ZnO-nanoparticles; X-ray diffraction; Dipole-Dipole interaction; Antibacterial activity.
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[2] Cheng, H.C.; Chen, C.F.; Tsay, C.Y. Transparent ZnO thin film transistor Fabricated by sol–gel and chemical bath deposition combination method, Appl. Phys. Lett. 2007, 90, 012113 (3 pages)
[3] Sahay P.P.; R.K. Nath, Al-doped zinc oxide thin films for liquid petroleum gas (LPG) sensors, Sens. Actuators B. 2008, 133, 222-227
[4] Shinde, S.S.; Shinde, P.S.; Bhosale, C.H.; Rajpure, K.Y. “Zinc oxide mediated heterogeneous photo catalytic degradation of organic species under solar radiation,†Journal of Photochemistry and Photobiology B, 2015, 104, 425–433
[5] Du, S.F.; Tian, Y.J.; Liu, H.D.; Liu, J.; Chen, Y.F. Calcination effects on the properties of gallium-doped zinc oxide powders, J. Am. Ceram. Soc. 2006, 89, 2440–2443
[6] Zhang, W.H.; Zhang W.D.; Zhou, J.F. Solvent thermal synthesis and gas sensing properties of Fe-doped ZnO, J. Mater. Sci. 2016, 45, 209-215
[7] Serier, H.; Gaudon M.; Menetrier, M. Al-doped ZnO powdered materials: Al solubility limit and IR absorption properties, Solid State Sci. 2009, 11, 1192-1197
[8] Suwanboon, S.; Amornpitoksuk, P.; Bangrak, P. Synthesis, characterization and optical properties of Zn1-xTixO nanoparticles prepared via a high-energy ball milling technique, Ceram. Int. 2011, 37, 333–340
[9] Meng, F.; Yin, J.; Duan, Y.Q.; Yuan, Z.H.; Bie, L.J. Co-precipitation synthesis and gas sensing properties of ZnO hollow sphere with porous shell, Sensor Actuator B. 2011, 156, 703-708
[10] Wang, H.; Baek, S.; Song, J.; Lee, J.; Lim, S. Microstructural and optical characteristics of solution-grown Ga-doped ZnO nanorod arrays, Nanotechnology, 2008, 19, 075607 (6 pages).
[11] Zhi, M.; Zhu, L.; Ye, Z.; Wang, F.; Zhao, B. Preparation and properties of ternar ZnMgO nanowires, J. Phys. Chem. B: 2005, 109, 23930-23934
[12] Wang, R.C.; Liu, C.P.; Huang, J.L.; Chen, S.J. Single-crystalline Al ZnO nanowires/nanotubes synthesized at low temperature, Appl. Phys. Lett. 2006, 88, 023111 (3 pages)
[13] Serier, H.; Gaudon, M.; Menetrier, M. Al-doped ZnO powdered materials, Al Solubility limit and IR absorption properties, Solid State Sci. 2009, 11, 1192-1197
[14] Verma, A.; Khan, F.; Kar, D.; Chakravarty, B.C.; Singh, S.N.; Husain, M. Sol–gel Derived aluminum doped zinc oxide for application as anti-reflection coating in terrestrial silicon solar Cells, Thin Solid Films, 2010, 518, 2649-2653
[15] Ogi, T.; Hidayat, D.; Iskandar, F.; Purwanto, A.; Okuyama, K. Direct synthesis of highly crystalline transparent conducting oxide nanoparticles by low pressure spray pyrolysis, Adv. Powder Technol. 2009, 20, 203-209
[16] Chunqiao, G.; Changsheng, X.; Mulin, H.; Yanghai, G.; Zikui, B.; Dawen, Z. Structural characteristics and UV-light enhanced gas sensitivity of La doped ZnO Nanoparticles, Mater. Sci. Eng. B: 2007, 141, 43–48
[17] Maiyalagan, T.R.; Das, S.J. Optical studies of nano-structured La doped ZnO prepared by combustion method, Mat. Sci. Semiconductor Processing, 2012, 15, 308–313
[18] Anandan, S.; Vinu, A.; Lovely, K.L.P.S.; Gokulakrishnan, N.; Srinivasu, P.; Mori, T.; Murugesan, V.; Sivamurugan, V.; Ariga, K. Photocatalytic activity of La-doped ZnO for the degradation of monocrotophos in aqueous suspension, J. Mol. Catal. A: Chem. 2007, 266, 149–157
[19] Korake, P.V.; Dhabbe, R.S.; Kadam, A.N.; Gaikwad, Y.B.; Garadkar, K.M. Highly active lanthanum doped ZnO nanorods for photodegradation of metasystox, J. Photochem. Photobiol. B: Biol. 2014, 130, 11-19
[20] Zhang, .; Sun, X.; Pan, L.; Li, H.; Sun, Z.; Sun, C.; Tay, B. K. Carbon nanotube–ZnO nanocomposite electrodes for supercapacitors, Solid State Ionics, 2009, 180, 1525–1528
[21] Chen, H.C.; Lin S.F.; Huang, K.T.; Thorn-like ZnO/CNT composites via the hydrothermal method with different seed layer, Appl Opt. 2014 , 53, A242-A247
[22] Vyas, R.; Sharma, S.; Gupta, P.; Prasad, A.K.; Tyagi, A.K.; Sachdev, K.; Sharma, S.K. CNT-ZnO Nanocomposite Thin Films: O2 and NO2 Sensing, Adv. Mater. Res. 2012, 585, 235-239
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