Wound healing potential of medicinal plants with their screening models: A comprehensive review

  • sukhbir Kaur

Abstract

A wound is a breakage in tissue continuity that can be produced by physical, chemical and thermal damage. It is a generally called as physical injury that cause opening and breaking of skin. Healing of chronic cutaneous wound is a big problem and it involves the restoration of continuity after wounding. Wounds are treated with various medicinal herbs or their extracts. Plants provide various remedies to mankind and herbal plants are nature’s gift used to treat wound with much lesser side effects. Some of those plants are Acalypha langiana, Tinospora cardifolia, Tragia involucrata, Napoleona Imperialis, Prosopis cineria, Lawsonia alba,Ginkgo biloba, Aloe vera, Catharanthus roseus. This review discusses about the wound healing potential of herbal plants and provides overview on wound healing problems and solution.

A wound is a breakage in tissue continuity that can be produced by physical, chemical and thermal damage. It is a generally called as physical injury that cause opening and breaking of skin. Healing of chronic cutaneous wound is a big problem and it involves the restoration of continuity after wounding. Wounds are treated with various medicinal herbs or their extracts. Plants provide various remedies to mankind and herbal plants are nature’s gift used to treat wound with much lesser side effects. Some of those plants are Acalypha langiana, Tinospora cardifolia, Tragia involucrata, Napoleona Imperialis, Prosopis cineria, Lawsonia alba,Ginkgo biloba, Aloe vera, Catharanthus roseus. This review discusses about the wound healing potential of herbal plants and provides overview on wound healing problems and solution.

Key words: wound healing, herbal remedies, open wound, close wound, models.

Keywords: Key words, wound healing, herbal remedies, open wound, close wound, models.

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Author Biography

sukhbir Kaur

Associate Professor

Deptt. of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.

References

References:

1. Esimone, CO, Ibezim EC, Chah, KF, et al. Factors affecting wound healing. Journal of Pharmaceutical Allied Sciences. 2005; 3(1):294 -299.
2. Avinash G, Priyanka B, et al.Wound healing potential of indian medicinal plants. International journal of pharmacy review and research.2013; 2: 75-87.
3. Mittal A, Sardana S, Pandey, A, et al. Herbal boon for wounds. International Journal of Pharmacy and Pharmaceutical Sciences.2013; 5:1-12.
4. Yogesh S, Jeyabalan G, Ramandeep S, et al.Current aspects of wound healing agents from medicinal plants. Journal of medicinal plants studies. 2013; 1:1-11.
5. Alam G, Singh MP, et al. Wound healing potential of some medicinal plants. International Journal of Pharmaceutical sciences Review and Research. 2011; 9: 136-145.
6. Sudha Bhargavi, Amaresh Kumar, Ranjith Babu, et al. Ancient and Modern View of Wound Healing: Therapeutic Treatments. Research Journal of Pharmaceutical, Biological and Chemical Sciences.2011; 2(3): 474.
7. Amaresh Kumar, Pavan Kumar, Ranjith Babu et al. Review Article of Ancient and Modern View of Wound Healing: Therapeutic Treatments. Research Journal of Pharmaceutical, Biological and Chemical.2011; 2: 475.
8. Lazarus GS, Cooper DM, Knighton DR et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Archives of dermatology .1994; 130: 489-493.
9. Menke NB, Ward KR, Witten TM, et al. Impaired wound healing. Clinical Dermatology.2007; 25: 19-25.
10. T Velnar, T Bailey,V Smrkolj, et al. The wound healing Process:An overview of the cellular and molecular mechanism. Journal of international Medical Research. 2009;37: 1528-1542.
11. DuBuc T Q, Traylor K N, Martindale M Q, et al. Cellular and molecular features of wound healing Initiating a regenerative response in the cnidarian Nematostella vectensis. Journal of B.M.C. Biology.2014; 12:20.
12. Kiwanuka E, Eriksson E, et al. Harnessing growth factors to influence wound healing. Clinics in Plastic Surgery.2012; 39: 239-248.
13. Guo S, DiPietro LA, et al.Wound Healing and Tissue Regeneration.2010; 3: 219-229.
14. 14.Badri P N, Renu S, et al. Role of Medicinal Plants in Wound Healing. Research Journal of Medicinal Plants. 2011; 4: 392-405.
15. 15.Hess CT, et al. Understanding the barriers to healing. Advanced skin wound care. 2012; 25: 239-240.
16. 16.Sabale P, Bhimani B, Prajapati, et al. An overview of medicinal plants as wound healers. Journal of applied Pharmaceutical Science. 2012; 2: 143-150.
17. Barrientos S, Stojadinovic O, Golinko MS, Brem H, et al. Growth factors and cytokines in wound healing .Wound Repair and Regeneration. 2008; 16: 585-601.
18. Guo S, DiPietro LA, et al.Wound Healing and Tissue Regeneration.2010; 3: 219-229.
19. Adeir Moreira Rocha, Beatriz Juliao Vieira , et al. Effects of low-level laser therapy on the progress of wound healing in humans.2007:6: 258-266.
20. Sibbald GR, Woo K, Ayello AE, et al. Increased bacterial burden and infection:The story of Nerds and Stones. Advances in skin & wound care .2006; 19: 447-461.
21. Tsokos M, Heinemann A, Puschel K, et al. Pressure sores: epidemiology, medico-legal implications and forensic argumentation concerning causality. International Journal Legal Medicines.2000: 113: 283-287.
22. Canales M, T Hernandez, M.A Roudriguez-Monroy, C.M Flores, M Jimenez, et al. Evaluation of antimicrobial activityof Acalypha monostachya:(Euphorbiaceae). African Journal of Pharmacy and pharmacology.2011; 5(5): 640-647.
23. Chitra, Ilango K, et al. Tropical Journal of Pharmaceutical Research. 2010; 9(3): 223-230.
24. 15. Sajithlal GB, et al . Influence of aloe vera on collagen turnover in healing of dermal wounds in rats .Indian Journal of Experimental Biology.2000; 36:896-901.
25. Subhashini T, Krishnaveni B, Srinivas Reddy, et al. Anti inflammatory activity of leaf extract of Alternanthera sessilis.2010; 2(1): 54-56.
26. Pujar PP, Swaikar, et al. A new germacranolide from a pallens. Journal of Pharmacognosy.2000; 5:590-2.
27. Barua Talukdar, et al. A evaluation of wound healing activity of methanolic extractbof Azadirachta Indica in rats .Pharmacology online .2010; 1:70-77.
28. G Don, Rashmi Y, et al. A study of phytochemical constituents and pharmacological actions of Trigonella foenumgraecum. International journal of pharmacy and technology. 2011; 3: 1022-1028.
29. Praveen kumar, K Nishteswar, et al. Phytochemical and Pharmacological profiles of Clerodendron Serratum: A review. International Journal of Research Ayurveda Pharm.2011; 4(2): 3276-278.
30. Poornima BS, Hedge, Pradeep, et al. Pcological review on Clerodendron serratum linn.Moon .Journal of Pharmacognosy and Phytochemistry.2015; 3(5):126-130.
31. Kaliyaperumal Ashokkumar, Kuamrakurubaran selvaraj, Saradha Devi, Muthukrishnan, et al. Cynodon dactylon :An updated review of its Photochemistry and Pharmacology. Journal of Medicinal plants Research.2013; 7(48):3477-3483.
32. Amrita Asthana, Anil Kumar, Sumit Gangwar, et al. Pharmacological perspectives of cynodon dactylon. Research journal o f Pharmaceutical, Biological and Chemical Sciences.2010; 2:71-76.
33. Wang Limei, Waltenberger Birgit, Pferschy Wenzig, Blunder Martina, Liu Xin, et al. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): A review. Biochemical Pharmacology. 2014; 92 (1): 73–89.
34. Jian S, Wang L, Nan P, Zhong Y, et al. Chemical composition of the essential oil of Elephantopus scaber from Southern China. Nat. J. Med. 2004; 59(5-6): 327-9.
35. Sandeep B, Patil, Nilofar Naikwad, Chandrakant Magdum, et al. Review on Phytochemistry and Pharmacological aspects of Euphorbia hirta linn. Journal of pharmaceutical research health care. 2009; 1: 113-133.
36. Kumar S, Malhotra R, Kumar D, et al. Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities. Journal of Pharmacognosy Review. 2010; 4 (7): 58–61.
37. Bairy kL, et al. Wound healing profile of Gingko Biloba .Journal of Natural Remedies.2001; 25-27.
38. S Pimenta, et al. Floral biology and artificial polinization in phydic nut. International Journal Medicinal Plants. 2009; 9:1073-1077.
39. Jones CD, et al. A review of Jatropha curcas: an oil plant of unfulfilled promise.The Genetic Basis of Drosophila sechellia's Resistance to a Host Plant Toxin. International Journal Medicinal Plants. 2000; 19(1): 1-15.
40. Muhammad I U, et al. African Journal of pharmacy & pharmacology.2011; 5:1638-1647.
41. Orthan I, kupeli E, et al. Journal of Ethnopharmacology.2007; 1:146-50.
42. Nizam Uddin, Bin S et al. International centre for chemical and biological sciences. 2013; 35: 476.
43. Deng, Shixin, Palu, et al. Journal of natural product. 2007; 5:859-62.
44. Morton J, et al. The ocean-going noni, or Indian Mulberry (Morinda citrifolia, Rubiaceae) and some of its “colorful” relatives. Economic Botany.1992; 149 (4): 1899–1908.
45. Harish K, Handral, Anup Pandith, Shruthi, et al. A review on Murraya Koenigii: Multipotential Medicinal Plant. Asian Journal of Pharmaceutical Clinical Research. 2012; 5: 5-14.
46. Vandana Jain, Munira Momin, Kirti Laddha, et al. Murraya Koenigii: An Updated Review . International Journal Of Ayurvedic And Herbal Medicine. 2012; 4: 607-627.
47. Gopalkrishnan M, et al. Chemical compositiion and mace. Journal of spices aromatic crops.1992; 1: 49-54.
48. Martin Chukwudi Uchegbu, Cynthia Okere, Ifeanyi Princewill, et al. Evaluation of Proximate and Phytochemical Compositions of Fermented Raw and Fermented Napoleona Imperialis Seed and Their Feeding Values on Finisher Broilers. Nature and Science.2010; 8(4).
49. Alaekwe Ikenna obiora, Mojekwu Okwuchukwu, et al. Composition and Utilization of Napoleona imperialis Fruits. Journal of Natural Sciences Research.2013; 3: 160.
50. Stellaa Robertson, N Narayana, Ravi Nargis, et al. Toxicity evaluation on hydroalcholic extract of leaf and stem bark of Prosopis Cineria. International Journal of Pharmacy and Pceutical Sciences .2012; 4(3):113-118.
51. Patil Hari, Dattatraya K, et al. Review Article Pterocarpus Marsupium: A valuable medicinal plant in diabetes management. International Journal of Applied Biology and Pharmaceutical Technology.2011; 2: 0976-4550.
52. Bhawana P, Divya G, et al. Physiochemical analysis of Pterocarpus santalinus. Indian Journal of Science Research. 2014; 1:201-204.
53. Shunjun Xu, Liu Yang, Runtao Tian. Species differentiation and quality assessment of Radix Paeoniae Rubra (Chi-shao) by means of high-performance liquid chromatographic fingerprint. Journal of chromatography .2009; 11: 2163-2168.
54. Mathew AD, Taranalli AD, Torgal SS, et al. Journal of Pharmaceutical Biology 2004; 42: 8–12.
55. K Madhuri, K Elango, S Ponnusankar, et al. Review of its traditional uses, phytochemistry and pharmacology. 2011.
56. Congo Brazzaville, M Nzikou, Matos G, Bouanga Kalou et al. Chemical Composition on the Seeds and Oil of Sesame (Sesamum indicum L.). Advance Journal of Food Science and Technology.2009; 1(1): 6-11.
57. B Ndangui, Pambou Tobi, Kimbonguila Silou, Linder Desobry, et al. Nutritional, Medicinal and Industrial Uses of Sesame (Sesamum indicum L.) Seeds - An Overview.2010; 75: 159-168.
58. M.B, Yelne .,P.C,Sharma.Pcognostic study of Brahati :root and fruit.1989; 11 : 70-83.
59. Saraswathi Motamarri , et al. Terminalia bellirica. A review. International journal of research in pharmaceutical sciences. (2012), (3).
60. Kirti S, NP Mishra, J Singh, et al. Tinospora cardifolia, a reservoir plant for therapeutic applicant. Indian Journal of.Traditional Knowledge. 2004; 3: 257-270.
61. N.Venkat Rao, et al. Pharmacological evaluation of root extracts of tragia involucrata. International Journal Pharmaceutical Science Drug Research. 2007; (2): 236-244.
62. Rashmi Y, G. Don, et al. A study of phytochemical constituents and pharmacological actions of Trigonella foenumgraecum. International journal of pharmacy and technology.2011; 3:1022-1028.
63. Ahsanul Haque, Musfizur Hassan, Atanu Das, Bilkis Begum,Yousuf Ali, et al. Phytochemical investigation of Vernonia cinerea (Family: Asteraceae). Journal of Applied Pharmaceutical Science.2012; 2(6):79-83.
64. D Pradhan, PK Panda, G Tripathy, et al. Wound healing activity of metahanolic andaqueous xtract of Vernonia arborea buch. Natural product radiance. 2009; 8(1): 6-11.
65. Anita R, Anupam S, et al. The genus Vitex. A review of pharmacognosy. Journal of pharmacognosy. 2013; 14: 188–198.
66. Anam EM, et al. Antiinflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae) Phytomedicine. . Journal of Phytomed. 2001; 8(l): 24-7.
67. Meena Prabha, Chendraya Perumal, Praveen Kumar, Soundarrajan, S Srinivasan, et al. Review Article Pharmacological activities of Abrus precatorius (L.) seeds . International Journal of Pharmaceutical and Medicinal Research Journal homepage. 2015; 3(2):195-200.
68. Schmelzer G.H, Gurib-Fakim, et al. Plant Resources of Tropical Africa Medicinal.
69. PL Rajagopal, K Premaletha, et al. International Journal of pharmaceutical, chemical and biological sciences.2013;3:672-679.
70. Jain S, Jain N, Tiwari A, Balekar N, Jain D K, et al. Asian Journal of Research Chem. 2009; 2: 135-138.
71. Anjoo Kamboj, Ajay Kumar Saluja, et al. Bryophyllum pinnatum (Lam.) Kurz:A review on Phytochemical and pharmacological profile. 2009; 6: 364-374.
72. Chimkode R, Patil M B, Sunil S, Reddy Patil N, Nitin Agarwal, Ashish Tripathi, et al.. International Journal of Pharmacology Biological Sciences.2008; 2 (3):153-156.
73. Xu C, Wang ZT, et al. Chemical constituents from root of Andrographis paniculata. Journal of Spectroscopy .2011; 3: 317-21.
74. Sumitra M, Manikandan P, Suguna L, et al. International Journal of Biochem Cell Biology. 2005; 37: 566–573.
75. Firdaus Rana, Mazumder Avijit, et al. Review on Butea Monosperma. International Journal of research in pharmacy and chemistry. 2012, (4).
76. Khan M, Patil PA, Shobha JC, et al. Journal of Natural Remedies. 2004; 4: 41–46.
77. Anjoo K, Ajay K S, et al. Ageratum conyzoides L. A review on its phytochemical and pharmacological profile.2009; 2: 59-68.
78. Narendra nalwaya, Gaurav pokharna, Lokesh deb, Naveen kumar Jain, et al. International Journal of Pharmaceutical Sciences. 2009; 1:176-181.
79. Suresh K, Suresh E, S Kalavathy, et al.Review on a potential herb Calotropis gigantea (L.). Scholars Academic Journal of Pharmacy .2013; 2: 135-143.
80. Ufuk koca, Ipek Pesin Suntar , Esra kupeli Akkol, Demet Yilmazer Murat Alper et al. eCAM. 2009; 1-7.
81. Madhavan V, Yadav DK, Murali A, Yoganarasimhan SN, et al.Journal of Indian Drugs. 2009, 3: 209-213.
82. Smith Varadharajan Madhavan , Dinesh Kumar Yadav , Magadi Gurudeva , Sunkam Yoganarasimhan, et al. Pharmacognostical studies on the leaves of Colebrookea oppositifolia Smith. Asian Journal of Traditional Medicines.2011; 4.
83. Eesha B R, Meena kumari, Mohanbabu Amberkar, Sarath babu, Rajsekhar, Neelesh kumar, et al. APJTM. 2010;783-787.
84. Kuppast I J, Vasudeva nayak, et al. Journal ofNatural Product Radiance. 2006; 2: 99-101.
85. Priya KS, Gnanamani A, Radhakrishnan N, Babu M, et al. Journal of Ethnopharmacology .2002; 83: 193–199.
86. Ghias Uddin, Abdur Rauf and Samina Akhtar, et al. Studies on Chemical Constituents, Phytochemical Profile and Pharmacological Action of Datura alba. Middle-East Journal of Medicinal Plants Research. 2012; 1: 14-18.
87. D. C. Odimegwu , E. C. Ibezim , C. O. Esimone, C. S. Nworu , F.B.C. Okoye , et al. Wound healing and antibacterial activities of the extract of Dissotis theifolia (Melastomataceae) stem formulated in a simple ointment base. Journal of Medicinal Plants Research .2008; 1; 011-016.
88. E. C. Ibezim , C. O. Esimone, C. S. Nworu , F.B.C. Okoye , et al. Wound healing and antibacterial activities of the extract of Dissotis theifolia (Melastomataceae) stem formulated in a simple ointment base. Journal of Medicinal Plants Research .2008; 1; 011-016.
89. Sreenivasan Sasidharan, Rajoo Nilawatyi, Rathinam Xavier, Lachimanan Yoga Latha Rajoo Amala, et al. Molecules. 2010; 15: 3186-3199.
90. Barker TW, Worgan, et al. The utilization of palm oil processing effluents as substrates for microbial protein production by the fungus Aspergillus oryzae. Journal of Applied Microbiology & Biotechnology.1981; 4: 234-240.
91. Rasik AM, Shukla A, Patnaik GK, Dhawan BN, Kulshrestha DK, Srivastava S, et al. Indian Journal of Pharmacology.1996; 28: 107–109.
92. Sheikh Arshad Ahmed, Sayyed Nazim, Shaikh Siraj, et al. A pharmacological review: Euphorbia neriifolia linn. International Research Journal of Pharmacy. 2011; 5: 41-48.
93. Jagadish N R N, Mohmood R, et al.Journal of Indian drugs. 2009; 464: 342-346.
94. Singh B, Gambhir SS, Pandey VB, Joshi VK, et al. Anti-inflammatory activity of Echinops echinatus. 1989.
95. Singh SDJ, Krishna V, Mankani KL, Manjunatha BK, Vidya SM, Manohara YN, et al. Indian Journal of Pharmacology. 2005; 37: 238–242.
96. Sachin Hiradeve,Vinod D, Ranagri, et al. Elephantopus scaber Linn.: A review on its ethnomedical, phytochemical and pharmacological profile. Journal of Applied Biomedicine.2014; 12:49-61.

97. Kishore GS, Kumar BS, Ramachandran S, Saravanan M, Sridhar SK, et al. Indian Drugs. 2010; 38: 355–357.
98. Kumar Anil, Dora Jyotsna, et al.Review on Glycyrrhiza glabra. Journal of Pharmaceutical and Scientific Innovation.2012; 1(2):1-4.
99. Mathew AD, Taranalli AD, Torgal SS, et al. Pharmaceutical Biology. 2004; 42: 8–12.
100. Katarina Savikin, Nebojsa Menkovic, Gordana Zdunic, et al. Antimicrobial activity of Gentian lutea L. extracts.2009;64:339-342.
99. Megha jha, Versha Sharma, Nitin Nema, Tahziba hussain, et al. Pharmacologyonline. 2009; 3; 356-360.
100. Anandhan Vignesh, Rama Purushothaman, et al. Chemical composition and antioxidant activity of essential oil from Glycosmis pentaphylla. International Journal of botany and research.2014; 4(5):19-28.
101. Gupta A, Kumar R, Pal K, Banerjee PK, Sawhney RC. Journal of Lower Extremity Wounds. 2005; 4: 88–92.
102. Geetha Suryakumar, Asheesh gupta, et al. Medicinal and therapeutic potential of sea buckthorn (plant ). Journal of ethnopharmacology.2011; 138: 268-278.
103. Reddy JS, Rao PR, Reddy MS, et al. Journal of Ethnopharmacology .2002; 79: 249–251.
104. Yesmin begum, et al. Antibacterial, Antioxidant and cytotoxic activities of Heliotropium Indicum. International Journal of science and technology.2014; 23(1):1564-1569.
105. Hemalatha S, Subramanian N, Ravichandran V, Chinnaswamy K, et al. Indian Journal of Pharmaceutical Sciences .2001; 63: 331–333.
106. M Sivagamy, NS Jagananthamn, R Senthamarai, et al. Anti Inflanmmatory of Indigofera enneaphylla Linn.in rats. International Journal of Pharmaceutical and chemical science .2012; 1(3):1234.
107. Nayak BS, Udupa AL, Udupa SL, et al. Fitoterapia .1999; 70: 233–236.
108. Somashekar Shetty, Udupa SL, Udupa AL, Vollala VR, et al. Saudi Medical Journal .2006; 27(10): 1473-1476.
109. Shivananda B, Jullien marshall, Godwin Isitor. Indian Journal of Experimental Biology .2010; 48:572-576.
110. Alaekwe, Ikenna obiora, Mojekwu Okwuchukwu, et al. Composition and Utilization of Napoleona imperialis Fruits. Journal of Natural Sciences Research.2013; 3: 160.
111. Singh, Vishwabhan., Vimal, Birendra., Suvagiya, Vishal. A review on ethnomedical uses of Ocimum Sanctum (Tulsi).International research journal of Pharmacy.2011; 2(10):1-3.
112. Sharma Y, Jeyabalan J, Singh R, et al.Current aspects of wound healing agents from Medicinal plants: a review. Journal of medicinal Plants Studies.2013; 1: 2320-3862.
113. Ipek Pesin, Ufuk koca, Esra Akkol, Demet Yilmazer, Murat Alper, et al. Journal of eCAM. 2009; 1-7.
114. Devi Priya, E.A Siril, et al. Pharmacognostic Studies on Indian Madder (Rubia cordifolia L.) Journal of Pharmacognosy and Phytochemistry.2013; 1(5): 112-119.
115. Günter Matzke-hajek, Heinriche Weber, et al. A survey of the Rubus Species (Rosaceae). Anales Jardín Botánico de Madrid. 1999; 57(1): 25-35.
116. Gajalakshmi S, Vijayalakshmi S, Devi Rajeswari, et al. Pharmacological activities of Catharanthus Roseus: A Perspective Review. International Journal of Pharma and Bio Sciences. 2013; 4(2): 431 – 439.
117. Rajha S, Al Naimi, Eman Taee, et al. Comparative pathological and cytogenetical study of ethanolic extract of Vinca rosea L. and Vinblastine in treating mammary gland adenocarcinoma implanted mice. Kufa Journal for Veterinary Medical Sciences. 2011; 2(1): 646.
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Kaur sukhbir. Wound healing potential of medicinal plants with their screening models: A comprehensive review. JDDT [Internet]. 15Jan.2016 [cited 16Apr.2024];6(1):56-. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1184