FORMULATION DEVELOPMENT AND RELEASE STUDIES OF ZIDOVUDINE SUPPOSITORIES
The present manuscript deals with the study to formulate and evaluate suppository for the successful delivery of Zidovudine through rectal administration. Zidovudine has tendency to cause gastric ulcer making it necessary to explore safer routes of its administration. Melt Fusion method was used for the preparation of suppositories using glycerogelatin and Emulsified glycerogelatin as suppository base. The prepared suppositories were evaluated for their visual characteristics, physicochemical properties like dimensions, weight variation, melting time, disintegration time, drug content and in-vitro drug Â release characteristics. The release was found to be greater in emulsified suppositories with satisfactory disintegration time.Keywords: suppository, Fusion method, Zidovudine
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