FORMULATION DEVELOPMENT AND RELEASE STUDIES OF ZIDOVUDINE SUPPOSITORIES

  • N Santhi Priya Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India
  • CH Swaroop Reddy Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India
  • CH Gowtham Sai Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India
  • G Madhusudana Rao Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India
  • G Lakshman Reddy Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India
  • M Santhosh Aruna Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Abstract

The present manuscript deals with the study to formulate and evaluate suppository for the successful delivery of Zidovudine through rectal administration. Zidovudine has tendency to cause gastric ulcer making it necessary to explore safer routes of its administration. Melt Fusion method was used for the preparation of suppositories using glycerogelatin and Emulsified glycerogelatin as suppository base. The prepared suppositories were evaluated for their visual characteristics, physicochemical properties like dimensions, weight variation, melting time, disintegration time, drug content and in-vitro drug  release characteristics. The release was found to be greater in emulsified suppositories with satisfactory disintegration time.

Keywords: suppository, Fusion method, Zidovudine

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Author Biographies

N Santhi Priya, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

CH Swaroop Reddy, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

CH Gowtham Sai, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

G Madhusudana Rao, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

G Lakshman Reddy, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

M Santhosh Aruna, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., India

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How to Cite
1.
Priya N, Reddy C, Sai C, Rao G, Reddy G, Aruna M. FORMULATION DEVELOPMENT AND RELEASE STUDIES OF ZIDOVUDINE SUPPOSITORIES. JDDT [Internet]. 15May2015 [cited 29Sep.2020];5(3):72-5. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1149