PREPARATION OF CARBAMAZEPINE CHITOSAN NANOPARTICLES FOR IMPROVING NASAL ABSORPTION

  • Rajeshwar Kamal Kant Arya Department of Pharmacology, Osmania medical college, Hyderabad,Telangana, India.
  • Vijay Juyal Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University, Nainital, India
  • Nitin Kunwar Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University, Nainital, India

Abstract

In this study the nasal administration of carbamazepine has been studied using chitosan nanopartcles. The chitosan nanoparticles were prepared by ionic gelation of chitosan (100-300mg) with Tripolyphosphate sod (100-300mg in 100ml. Nine formulations were prepared, characterized and compared in terms of morphology (Transmission electron microscopy), drug content, particle size (zetasizer) and In-vitro drug release. In-vitro drug release studies were performed in Franz diffusion cell using phosphate buffer (buffer pH 5.5) as dissolution medium. The Chitosan nanoparticles had a mean size of 124.2±05 to 580±13nm, zeta potential were found to be +21 to 26.6 mV and the entrapment efficiency were found to be 65 to 72.7%. The in-vivo study was performed on Wistar rat, nanoparticles were administered through nasal route and compared with carbamazepine given by i.v. route, the results indicate that carbamazepine loaded chitosan nanoparticles enhances the drug absorption through nose. The results showed that the carbamazepine could be directly transported into the rat brain through nose and the possible side effects could be minimized.

Key Words: Carbamazepine, Chitosan Nanopartcles, Ionic Gelation, Epilepsy

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Author Biographies

Rajeshwar Kamal Kant Arya, Department of Pharmacology, Osmania medical college, Hyderabad,Telangana, India.
Department of Pharmacology, Osmania medical college, Hyderabad,Telangana, India.
Vijay Juyal, Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University, Nainital, India

Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University, Nainital, India

Nitin Kunwar, Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University, Nainital, India

Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University, Nainital, India

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1.
Arya R, Juyal V, Kunwar N. PREPARATION OF CARBAMAZEPINE CHITOSAN NANOPARTICLES FOR IMPROVING NASAL ABSORPTION. JDDT [Internet]. 16Apr.2016 [cited 30Sep.2020];5(3):101-8. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1090